Important risk disclosure

Please click here and read carefully the summary of the key features and risks specific to this fund stated in the offering document prepared by the relevant fund house before making any investment decision.

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IE00BFRSYJ83
Janus Henderson Global Life Sciences Fund

  • Equities
  • Global
  • USD Cash
  • Accumulating
Invest with
USD Cash
Payout type
Accumulating
Risk rating
6
About this fund
Description
The Fund invests in companies addressing unmet medical needs or improving health care efficiencies by understanding the science and business of health care.
Key information
Annual report
Key fact sheet
Prospectus
Factsheet
Our perspective
Why we think this fund is best-in-class
product
Product
Well-diversified portfolio balanced across Core, Emerging, and Opportunistic buckets in various healthcare sub-sectors.
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people
People
Led by an experienced PM who has 25 years of investment experience with a background in biochemical sciences and is supported by a team of 7 dedicated healthcare analysts with 3 PhDs in related fields.
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performance
Performance
Delivered a healthy track record since its inception in 2000 with superior long-term total returns against its peers.
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process
Process
Bottom-up driven approach which includes healthcare-sector specific ESG considerations such as drug pricing, waste management, carbon emission, and more. Resulting portfolio is well-diversified across geographies and subsectors with a sizable portfolio size of around 80 to 120 names. Strategy also allows for private company investments, giving investors the exposure to innovative, high-growth names in the space that potentially will progress towards a public listing.
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cost
Cost
Access to institutional share class with no trailer fees to achieve the lowest possible fees.
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selectionCriteria
How it fits in a portfolio
Investors should note that the Fund may experience periods of short-term volatility. This is due to the Fund's underweight to pharmaceuticals, especially the mega-cap pharma companies, and an overweight to innovative, smaller-sized biotechnology companies, which has nevertheless, historically contributed to superior long-term returns. Given this, as well as the strategy's specialised focus on the healthcare sector, this Fund should be used as a satellite allocation to complement a diversified core portfolio.
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Invest in this fund
Performance
Shows the total return of this accumulating fund, which includes dividends reinvested.
Total returns
All Time
230.40%
YTD
2.10%
1 month
6.14%
6 month
-3.36%
1 year
-11.56%
3 year
24.91%
5 year
31.90%
10 year
97.37%
As of Aug 2025
Distributions
This is an accumulating fund, so dividends are re-invested at the fund level.
Risk metrics
Max drawdown
-27.27%As of Aug 2025
Volatility
16.04%As of Aug 2025
Calendar returns
YearTotalJanFebMarAprMayJunJulAugSepOctNovDec
2025-5.9%-0.3%-4.5%-0.3%-5.7%2.3%-0.9%6.1%----
20243.3%2.8%3.8%1.7%-4.7%3.5%3.2%2.6%5.2%-2.4%-3.3%-0.7%-7.6%
20237.0%0.4%-4.3%2.6%4.0%-2.3%3.1%1.0%-1.4%-3.9%-6.3%7.4%7.6%
2022-2.9%-8.9%0.5%3.5%-6.8%-0.9%-0.8%3.7%-2.6%-2.9%8.4%6.0%-0.8%
20216.4%-1.0%0.1%-2.1%3.3%0.2%3.4%0.1%3.2%-4.0%4.5%-7.3%6.7%
Top Exposures
Eli Lilly and Co8.37%
AstraZeneca PLC4.55%
Johnson & Johnson4.53%
UnitedHealth Group Inc3.91%
Abbott Laboratories3.23%
Boston Scientific Corp3.07%
argenx SE ADR3.05%
AbbVie Inc3.04%
Sanofi SA2.97%
Novartis AG ADR2.62%
Top exposures represent up to 15 of the fund's largest exposures for each category. Allocation percentages may not sum up to 100% and can include negative values due to rounding or trading activities by the underlying fund managers, including short positions.
Fund fees
0.88% p.a.
Fund facts
ISIN
IE00BFRSYJ83
Fund house
Janus Henderson
Fund size
US$3.8B
As of 08 Sep 2025
Fund inception date
31 Oct 2013
Fund class currency
USD
Oldest share inception date
31 Mar 2000
Pricing frequency
Daily

Warning statements

  • All investments involve risks (including the possibility of loss of the capital invested) and the price of fund units may go up as well as down.
  • Past performance is not indicative of future performance.
  • Although this fund has been authorised by the Hong Kong Securities and Futures Commission (“SFC”), it does not imply an official recommendation or endorsement by the SFC nor does it guarantee the commercial merits of the fund or its performance.
  • If you are in any doubt, you should clarify with us or seek independent professional advice.

Risk Warnings Investment involves risk. Past performance is not an indicator nor a guarantee of future performance or returns. Projected performance or returns are not guaranteed to materialise. The value of investments and the income from them can go down as well as up, and you may not get the full amount you invested. Rates of exchange may cause the value of investments to go up or down. Individual stock performance does not represent the return of a fund.

The value of the fund can be volatile and can go down substantially within a short period of time. It is possible that a certain amount or all of your investment could be lost.

Generic risk warnings relating to collective investment schemes

Funds are not a bank deposit and not capital guaranteed, and is subject to investment risks, including the possible loss of the principal amount invested. There is no assurance that a fund will have sufficient liquidity to meet redemption requests and that the fund's investment objectives and strategies will be achieved.

The funds' investment may involve substantial market, currency, volatility, liquidity, regulatory and political risks. Some funds may use derivatives, whether for hedging or for investment purposes. The risks associated with derivatives include counterparty/credit, liquidity, valuation, volatility and market risks. The fund's volatility may increase or decrease from its derivative usage and such fund may suffer losses from its derivative usage. Do not invest in these funds unless you fully understand and are willing to assume the risks associated with them.

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